A novel nanofiber Cur-loaded polylactic acid constructed by electrospinning

Thi Thu Trang Mai, Thi Thu Thuy Nguyen, Quang Duong Le, Thi Ngoan Nguyen, Thi Cham Ba, Hai Binh Nguyen, Thi Bich Hoa Phan, Dai Lam Tran, Xuan Phuc Nguyen and Jun Seo Park

Abstract

Curcumin (Cur), extracted from the Curcuma longa L. plant, is well known for its anti-tumor, anti-oxidant, anti-inflammatory and anti-bacterial properties. Nanofiber mats of polylactic acid (PLA) loading Cur (5 wt%) were fabricated by electrospinning (e-spinning). Morphology and structure of the fibers were characterized by field emission scanning electron microscopy (FE-SEM) and Fourier transform infrared (FTIR) spectroscopy, respectively. The diameters of the obtained fibers varied from 200 to 300 nm. The release capacity of curcumin from curcumin-loaded PLA fibers was investigated in phosphate buffer saline (PBS) containing ethanol. After 24 h, 50% of the curcumin was released from curcumin-loaded PLA fibers. These results of electrospun (e-spun) fibers exhibit the potential for biomedical application