Optical nanoparticles: synthesis and biomedical application

Hong Nhung Tran, Thi Ha Lien Nghiem, Thi Thuy Duong Vu, Viet Ha Chu, Quang Huan Le, Thi My Nhung Hoang, Lai Thanh Nguyen, Duc Minh Pham, Kim Thuan Tong, Quang Hoa Do, Duong Vu, Trong Nghia Nguyen, Minh Tan Pham, Cao Nguyen Duong, Thanh Thuy Tran, Van Son Vu, Thi Thuy Nguyen, Thi Bich Ngoc Nguyen, Anh Duc Tran, Thi Thuong Trinh and Thi Thai An Nguyen

Abstract

This paper presents a summary of our results on studies of synthesis and biomedical application of optical nanoparticles. Gold, dye-doped silica based and core–shell multifunctional multilayer (SiO₂/Au, Fe₃O₄/SiO₂, Fe₃O₄/SiO₂/Au) water-monodispersed nanoparticles were synthesized by chemical route and surface modified with proteins and biocompatible chemical reagents. The particles were conjugated with antibody or aptamer for specific detecting and imaging bacteria and cancer cells. The photothermal effects of gold nanoshells (SiO₂/Au and Fe₃O₄/SiO₂/Au) on cells and tissues were investigated. The nano silver substrates were developed for surface enhanced Raman scattering (SERS) spectroscopy to detect melamine