Synthesize and survey the drug loading efficiency of the porous nano silica modified by gelatin

Uyen Vy Vo et al

Abstract

Recent research in drug delivery, gelatin stand out from all other natural polymer by its property such as biocompatible, biodegradable, reduced immunogenicity. Modify porous nano silica (PNS) by gelatin to use for drug delivery can avoid the detection of the human immune system. In this study, the coated PNS was successfully formed with spherical shape and diameter around 70 nm determined by transmission electron microscopy (TEM). Drug loading and release behaviors of doxorubicine@PNS-gelatin, in particular, were also tested. This study is expected to improve the stability of PNS for drug delivery system in cancer therapy.