Platinum (II) complexes and their nanoformulations: preparation, characterisation and cytotoxicity

Thi Hong Tuyet Phan, Thi Thu Huong Le, Ke Son Phan, Thi Lan Anh Tran, Hoa Du Nguyen, The Tam Le, Thi Tuong Vi Bui, Mai Huong Le, Thi Hong Ha Tran, Duc Huy Luu et al

Abstract

Development of novel drugs or drug delivery systems has attracted much attention of researchers. In this study, we aimed to prepare 2 new Pt(II) complexes with thiosemicarbazone and their nanoformulations for cancer treatment application. Pt(II)-camphor thiosemicarbazone/P1 and Pt(II)-camphor 4-phenyl thiosemicarbazone/P2) were successfully prepared and structurally confirmed by MS, IR, 1H-NMR, UV–vis spectroscopies and thermal analysis. From the complexes, 2 PLGA-based nanoformulations (nP1 and nP2) were synthesised with the average size of 50 nm by emulsification/evaporation method and investigated for their toxicity against Hep-G2, LU-1 and RD cancer cell lines. The results show that the Pt(II) complexes and their nanoformulations were potential for chemotherapy.